The authors suggest that CBD may improve flow because it widens blood vessels. The authors found that it lowered blood pressure in people at rest and in people under stress. Cannabidiol (CBD) has beneficial effects on disorders as varied as diabetes, Huntington's disease, cancer and colitis. The evidence now accumulating also suggests that CBD is beneficial for the cardiovascular system.
CBD acts directly on isolated arteries, causing both acute and time-dependent vasorelaxation. In vitro incubation with CBD improves vasrelaxant responses in animal models of altered endothelium-dependent vasorelaxation. CBD protects against vascular damage caused by an environment high in glucose, inflammation or the induction of type 2 diabetes in animal models and reduces the vascular hyperpermeability associated with such environments. A common theme throughout these studies is the anti-inflammatory and antioxidant effect of CBD.
In the heart, in vivo CBD treatment protects against ischemia and reperfusion damage and against cardiomyopathy associated with diabetes. Similarly, in a different model of ischemia-reperfusion, CBD has been shown to reduce infarct size and increase blood flow in animal models of stroke, sensitive to 5HT1A receptor antagonism. Although acute or chronic CBD treatment appears to have little effect on hemodynamics, CBD reduces the cardiovascular response to stress models, applied systemically or intracranially, inhibited by a 5HT1A receptor antagonist. In the blood, CBD influences white blood cell survival and death, white blood cell migration, and platelet aggregation.
Taken together, these preclinical data appear to support a positive role of CBD treatment in the heart and in the peripheral and cerebral vasculature. However, further work is needed to strengthen this hypothesis, establish mechanisms of action and determine if CBD-like responses would be observed in humans. To minimize cardiovascular damage, you can consider an oral dose, through a CBD edible, a tincture, or even a pure CBD oil. In addition, while the FDA has approved some CBD drugs to treat certain diseases, don't expect over-the-counter CBD to be safe or beneficial for heart failure, Lundgren says.
Unlike HPA, in rat SMA, AM251 reduced the potency of CBD, suggesting that CBD could act directly on the CB1 receptors in this vascular bed. We decided to examine the vasodilator response to CBD in experimental hypertension, since it is suggested that CBD has antihypertensive potency. In addition to the effects of CBD on the heart and vasculature, there is evidence that CBD also influences blood cell function. Unlike CBD responses in PAHs (see above) and AMF, capazepine, a TRPV1 receptor antagonist, did not produce the vasodilating effect of CBD in normotensive and hypertensive rats.
Taken together, these studies show that CBD influences both white blood cell survival and death, white blood cell migration and platelet aggregation, which could underpin CBD's ability to delay or prevent the development of cardiovascular disorders.
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