Cardiovascular effects This is due to the complex effects that cannabinoids have on the cardiovascular system, such as increasing the resting heart rate, dilating blood vessels and causing the heart to pump harder. Since CBD is a desensitizer of TRPV1 channels, it has a mild calming effect on the heart. In addition, it tends to lower the heart rate, which is beneficial for those living with hypertension or are at risk of having a heart attack. It also lowers the metabolic rate of the heart muscles.
However, it's worth noting that CBD only has a mild effect on the heart. When you use CBD oil, your liver breaks it down. During this process, it could interfere with medications for heart failure or other heart conditions. Just because a supplement is “natural” doesn't mean it's safe, Lundgren says.
Given the increasing use of CBD as a drug, these hemodynamic changes should be considered in people taking CBD. However, given our findings that CBD produced similar changes in cardiovascular parameters, albeit to a varying degree during rest and stress, this may indicate that CBD also has direct cardiovascular effects. They gave participants a large dose of CBD or a placebo before speaking in public and found that the group receiving CBD had lower levels of blood pressure, heart rate and anxiety. These hemodynamic changes should be considered in people taking CBD and suggest that more research is needed to determine if CBD plays any role in treating cardiovascular disorders.
This could also be due to the analgesic properties of CBD (3), which reduce cold stress and thus minimize the sympathetic response (which also explains why the cold pressure test was more affected by CBD than the stress test). We found that resting blood pressure was lower after subjects had taken CBD and that CBD attenuated the blood pressure response to stress, especially in periods before and after stress. Other studies have come to similar conclusions, leading CBD advocates to conclude that CBD can protect against or treat cardiac arrhythmias.